For Healthy Urinary Tract

Urinary tract infections (UTIs) are some of the most common bacterial infections. An estimated 20 to 50% of women have experienced a urinary tract infection (cystitis) at least once in their lifetime, and many of them suffer from recurring UTIs. In general, UTIs are painful. Women are affected more often because of their anatomy. Pregnancy and impaired vaginal microbiota are associated with the onset of UTIs in women, while aging, catheterisation, and prostate enlargement pre-condition UTIs in men. The most common cause of UTIs is Escherichia coli (Е. coli), which is found in 80% of cases.

Lactoflor UROBiotic+ is 100% natural: A synergetic combination of well-researched herbal extracts (Ursolia® containing an extract of Salvia officinalis, and Exocyan® containing cranberry extract), D-mannose, and a probiotic blend. With its scientifically proven beneficial properties, this combination was created for prevention and to maintain a healthy urinary system in both male and female. Through the use of natural ingredients, Lactoflor UROBiotic+ restores impaired balance and reduces the risk of recurring infection, while boosting the body’s natural protection.


Lactoflor UROBiotic+ is a 100% natural product (free of preservatives and GMO), which is suitable for both male and female. Based on an innovative probiotic blend of Ursolia®, D-mannose, and Exocyan®, this product:

• Provides fast relief upon initial symptoms of discomfort during urination.
• Is suitable for pregnant and breastfeeding women, diabetics, and children aged over 6 years.
• Does not cause resistance after long-term intake.
• Is suitable to take in combination with antibiotics.

Each capsule Lactoflor UROBiotic+ contains:

1. Probiotic blend: a unique selection of special strains (L.acidophilus, L.casei, B. bifidum, B.infantis, and B.longum) ensures an effective antagonistic effect against E.coli and beneficially conditions the urinary tract, vaginal flora, and immune system.

2. Ursolia® is a standardised extract of Salvia officinalis, high in ursolic acid and oleanolic acid. It has distinctive anti-proliferative, anti-oxidative and anti-microbial effects. Ursolic acid helps reduce urinary tract inflammation associated with E.coli. By inhibiting the activity of inflammatory cytokines, it helps alleviate discomfort and inflammation in the lower urinary tract.

3. Exocyan® - standardised dry cranberry extract, which have an anti-adhesion effect against E.coli and destroys the pathogen-receptor bond. Consequently, pathogenic bacteria fail to bind and are removed through urine.

4. D-mannose is 100% natural monosaccharide which exists in some red berries. Studies have demonstrated that D-mannose is able to remove and evacuate pathogenic bacteria. D-mannose blocks the binding of the uropathogenic bacteria E.coli and supports the process of passing pathogens into urine.

Benefits of UROBiotic+


Antibacterial therapy in acute, uncomplicated cystitis includes mostly antibiotic and uroantiseptic agents. But an increase in drug-resistant E.coli strains at present poses a risk of failure with this antibacterial therapy, as well as risk of more frequent recurrent infection, chronification, or intake of high doses of medication.

Natural products (such as UROBiotic+) which have specific anti-adhesion, anti-inflammatory and bacteriostatic effects on the urinary tract can be used as an appropriate alternative to traditional antibacterial agents, especially against recurring infections. UROBiotic+ helps limit the use of antibacterials and reduce the variety of drug-resistant strains, which present a significant problem for clinical practice and public health.


There is a well-established connection between vaginal microbiota and urinary tract infections. Most microorganisms in vaginal microbiota come from the gastrointestinal tract, and so we should ensure beneficial (good) bacteria to prevail within the intestinal microbiota.

Various scientific studies have demonstrated that the intake of probiotics maintains good immunity and regulates gastrointestinal and vaginal microbiota. These effects, in turn, can prevent urinary tract infections. It has been proven that beneficial bacteria (such as Lactobacillus) also have anti-bacterial effect, curbing the growth E.coli.



Lactobacillus acidophilus are part of vaginal microbiota. They disintegrate lactose into lactic acid (producing bacteriocins and creating unfavourable conditions for pathogens), stimulate the immune system, and curb development of infection and allergy.

L. casei boost immunity and acts directly against pathogens (viruses and bacteria).

Bifidobacterium sp, B. bifido, B. infantis and B. Longum stimulate production of anti-inflammatory molecules and boost the immune system. They aid metabolism — by synthesizing amino acids, lactic acid, acetic acid, other short-chain fatty acids, and B-group vitamins—and assist in fermentation of carbohydrates. These bacteria protect against pathogens via production of lactic acid and bacteriocins.


• Prophylaxis in recurrent urinary tract infections (UTI).
• Protection against infection in urolithiasis (kidney stones).
• Protection against infection during and after urinary catheterisation.
• Senile urethritis.
• Asymptomatic bacteriuria.
• Follow-up treatment after acute UTI.
• As concomitant therapy in parallel with antibiotic treatment.
• After urological procedures.



Physicians Appraisals

Lactoflor Opti6


Probiotic blend with Ursolia® for prevention of urinary tract infections.
Suitable for prophylaxis and prevention of recurrent urinary tract infections. A synergetic combination of well-researched herbal extracts (Ursolia® containing an extract of Salvia officinalis, and Exocyan® containing cranberry extract), D-mannose, and probiotic blend.


Lactoflor offers a full range of combined synbiotic products (prebiotics and probiotics) that contain selected strains of lactic acid bacteria, including Lactobacillus delbrueckii ssp. bulgaricus (Lactobacillus bulgaricus) and Streptococcus thermophilus, Lactobacillus acidophilus and Bifidobacterium ssp. Lactoflor is available in chewable tablets, capsules, or soluble sachets for children.